Chemical Chaperone and Inhibitor Discovery: Potential Treatments for Protein Conformational Diseases
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چکیده
منابع مشابه
Chemical Chaperone and Inhibitor Discovery: Potential Treatments for Protein Conformational Diseases
Protein misfolding and aggregation cause a large number of neurodegenerative diseases in humans due to (i) gain of function as observed in Alzheimer's disease, Huntington's disease, Parkinson's disease, and Prion's disease or (ii) loss of function as observed in cystic fibrosis and alpha1-antitrypsin deficiency. These misfolded proteins could either lead to the formation of harmful amyloids tha...
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ژورنال
عنوان ژورنال: Perspectives in Medicinal Chemistry
سال: 2007
ISSN: 1177-391X,1177-391X
DOI: 10.4137/pmc.s212